Animal PoisonLine puts it plainly: “If your pet is showing signs of collapse, convulsions, or breathing difficulties, seek immediate veterinary attention.” This page is for the situation where your pet has swallowed something and still seems fine. That is exactly when the dose matters — and exactly when there is still time to act.
Most pages tell you grapes are toxic. You already know that — it is why you are here at eleven at night. What you actually need to know is whether the amount your animal ate, at its body weight, is in a range that matters. This tool does that calculation using published veterinary toxicology thresholds, shows you the arithmetic, and tells you honestly when no threshold exists.
When am I in the clear?
The dose checker above tells you whether the amount matters. This tells you how long it matters for — when signs are expected to start, when they are expected to stop, and whether any published veterinary reference will actually say the words out of danger.
Of the eighteen substances below, exactly one — cholecalciferol — has a published sentence that amounts to an all-clear, and it turns on a blood test rather than on how your pet looks. Two more have a published recovery time. For the other fifteen the reference stops before the question does, and we say so rather than filling the gap.
Who to phone, by country
Every number below was read off the operator’s own website on 27 July 2026. We have not copied a single number from a third-party list, and where a country has no animal poison service we say so rather than sending you to a human helpline that does not cover pets.
| Country | Service | Number | Hours | Cost |
|---|---|---|---|---|
| United States | ASPCA Animal Poison Control Center [official] | (888) 426-4435 | 24/7 | A consultation fee applies. ASPCA does not publish the amount anywhere on its own site, so we will not quote one. |
| United States | Pet Poison Helpline [official] | (855) 764-7661 | 24/7 | $89 per incident, covering follow-up calls with you and your vet. |
| Canada | Pet Poison Helpline (no Canadian service exists) [official] | (855) 764-7661 | 24/7 | $89 USD per incident. Canada is named in their coverage. |
| United Kingdom | Animal PoisonLine [official] | 01202 509 000 | 24 hours | £35 from 8am-8pm Mon-Fri, £45 at all other times including bank holidays. Card payment taken automatically; Amex not accepted. For pet owners only — vets use VPIS. |
| Australia | Animal Poisons Helpline [official] | 1300 869 738 | 24/7 | Their own site contradicts itself — the sponsor page says the service is free for Australia and New Zealand, the homepage says consultations are available from $75 AUD. Ask when you call. |
| New Zealand | Animal Poisons Helpline [official] | 0800 869 738 | 24/7 | Same operator and the same fee contradiction as Australia. |
| France | CAPAE-Ouest, Oniris Nantes [official] | 02 40 68 77 40 | 08:30 to midnight | Free. Separate entry points published for vets and for the public. |
| France | CNITV, VetAgro Sup Lyon [official] | +33 (0)4 78 87 10 40 | 7 days, 08:30-00:00 | Cost not published. |
| Belgium | Antigifcentrum / Centre Antipoisons [official] | 070 245 245 | For animals: weekdays 08:00-22:00, weekends and holidays 10:00-22:00 | Free call. Note their own warning that human calls take priority. |
| Singapore | Animal Poisons Helpline [official] | 3106 4216 | 24/7 | Same operator as Australia; same fee ambiguity. |
| Netherlands | No owner-facing service [official] | — | — | The national centre covers animals but takes calls from professionals only. Call your own vet; the vet calls them. |
The thresholds this tool uses
Nothing here is our opinion. These are the published figures, quoted, with the source on every row.
| Substance | Species | Published thresholds | Source |
|---|---|---|---|
| Chocolate / cocoa | Dog | Mild signs from 20 mg/kg methylxanthine; cardiotoxic effects 40-50 mg/kg; seizures at 60 mg/kg or more. Milk chocolate ~62 g/kg potentially lethal. Concentrations: cocoa powder 28.5 mg/g, baking 15.5, dark 5.3-5.6, milk 2.3, white 0.04. | Merck Veterinary Manual |
| Chocolate / cocoa | Cat | No feline bands published. We do not calculate for cats. | Merck Veterinary Manual |
| Xylitol | Dog | Hypoglycaemia above ~100 mg/kg; liver failure possible above 500 mg/kg. | Merck / FDA |
| Xylitol | Cat | Not at risk. Merck: dogs are the only domestic species in which xylitol toxicosis has been reported. | Merck Veterinary Manual |
| Onion, garlic, chives, leek | Dog | Signs from 15-30 g/kg raw onion. Garlic is 3-5× more toxic. | Merck Veterinary Manual |
| Onion, garlic, chives, leek | Cat | Signs from 5 g/kg raw onion, or less than a teaspoon of cooked onion. Cats are the most susceptible species. | Merck Veterinary Manual |
| Macadamia nuts | Dog | Lowest reported toxic dose 2.4 g/kg. Usually self-limiting; most recover in 12-48 hours. | Merck Veterinary Manual |
| Paracetamol / acetaminophen | Cat | Toxicosis generally at 40-50 mg/kg, but signs have been reported at 10 mg/kg. One 500 mg tablet in a 4 kg cat is about 125 mg/kg. | Merck / VCA |
| Paracetamol / acetaminophen | Dog | No signs unless above 100 mg/kg; methaemoglobinaemia reported above 200 mg/kg. | Merck Veterinary Manual |
| Ibuprofen | Dog | GI toxicity 100-125 mg/kg; kidney failure 175-300 mg/kg; CNS effects above 400; potentially lethal above 600. | Merck Veterinary Manual |
| Ibuprofen | Cat | Merck states cats are affected at approximately half the dog dose. Our feline figures are derived from that sentence, not quoted. | Merck Veterinary Manual |
| Naproxen | Dog | Vomiting and tarry stools from 5.6 mg/kg daily. Half-life 74 hours — the most dangerous common human painkiller per milligram. | Merck Veterinary Manual |
| Cannabis / THC | Dog | Mild signs 0.3-0.5 mg/kg; moderate above 2-3 mg/kg. Probable lethal dose exceeds 3-9 g of plant material per kg. | Merck Veterinary Manual |
| Cholecalciferol (vitamin D) | Dog & cat | Signs from 0.1 mg/kg; tissue mineralisation above 0.5 mg/kg; acute lethal dose 13 mg/kg. Bait is typically 0.75 mg/g. | Merck Veterinary Manual |
| Bromethalin bait | Cat | LD50 0.4-0.71 mg/kg — five to eight times more sensitive than dogs. No antidote exists. | Merck Veterinary Manual |
| Bromethalin bait | Dog | LD50 2.38-5.6 mg/kg. Bait is 0.1-0.25 mg/g. | Merck Veterinary Manual |
| Ethylene glycol (antifreeze) | Dog | Minimum lethal dose 4.4-6.6 ml/kg. Antidote window 8-12 hours. | Merck / VCA |
| Ethylene glycol (antifreeze) | Cat | Minimum lethal dose 1.4 ml/kg — under a teaspoon for an average cat. | Merck Veterinary Manual |
| Grapes / raisins | Dog | No dose-response bands exist. Merck gives a risk trigger: more than one grape or raisin per 4.5 kg of body weight. | Merck Veterinary Manual |
| Lilies | Cat | No threshold at all. Pollen or vase water can cause fatal kidney failure. Irreversible if treatment is delayed 18+ hours. | FDA |
| Anticoagulant rat bait | Dog & cat | No companion-animal toxic dose is published. Bleeding appears 3-7 days later. | Merck Veterinary Manual |
| Permethrin on a cat | Cat | No feline threshold published. Merck: cats are more sensitive to pyrethroids. | Merck / Cornell |
| Nicotine | Dog & cat | No mg/kg threshold and no per-product content could be sourced. Narrow safety margin; rapid onset. | Pet Poison Helpline |
| Cooked bone, corn cob, avocado pit | Dog & cat | Mechanical obstruction, not poisoning. Failure to pass in 36-48 hours means surgery. | Merck Veterinary Manual |
Three things cat owners are rarely told
- Paracetamol. A dog tolerates up to 100 mg/kg. A cat can show signs at 10 mg/kg, because cats lack the liver enzyme that processes it. One standard 500 mg tablet in a 4 kg cat is roughly 125 mg/kg — a life-threatening dose from a single tablet.
- Dog flea treatment. Permethrin spot-ons sold for dogs cause seizures in cats, including when a cat grooms a dog that was treated hours earlier.
- Lilies. The FDA says dogs that eat lilies get at most minor stomach upset. For a cat, pollen licked off its own fur can cause fatal kidney failure within three days.
And one in the other direction, so cat owners are not frightened unnecessarily: xylitol. Merck states cats are not at risk of the hypoglycaemia or liver injury it causes in dogs.
Questions people ask at the worst moment
Should I make my dog vomit?
Not unless a vet or a poison service has specifically told you to. Cornell’s veterinary college puts it directly: do not try to make the animal vomit unless you have been specifically told to The AVMA says to always contact your veterinarian or poison control centre before inducing vomiting. Merck lists salt, syrup of ipecac and finger-down-the-throat as inappropriate methods. It is also actively dangerous after corrosive substances, petroleum products, or if your pet is drowsy or unsteady — and there is no safe way to do it at home in a cat, because hydrogen peroxide must not be used in cats.
My dog ate one grape. Is that dangerous?
There is no honest dose answer, and anyone who gives you one is guessing. Merck now attributes grape toxicity to tartaric acid, whose concentration varies from fruit to fruit — so the same weight of grapes is not the same dose twice. What Merck does give is a risk trigger: more than one grape or raisin per 4.5 kg of body weight may contain enough tartaric acid to risk kidney damage. For a small dog, one grape can cross that line. Phone rather than wait.
How much chocolate is actually dangerous for my dog?
It depends on three things: the type of chocolate, the amount, and your dog’s weight. Merck’s bands are 20 mg/kg of methylxanthine for mild signs, 40-50 for heart effects and 60 or more for seizures. Because dark chocolate carries about 5.3 mg per gram and milk chocolate about 2.3, two 10 g squares of dark chocolate is around 106 mg — which is under the mild band for a 10 kg dog but over it for a 3 kg one. That is exactly the calculation the tool at the top of this page does for you.
My pet seems completely fine. Do I still need to do anything?
For several of these, yes — and this is the most important thing on the page. Onion and garlic damage red blood cells slowly, with anaemia typically appearing three to five days later. Anticoagulant rat bait causes no visible bleeding for three to seven days. Xylitol liver injury may not show for 24-48 hours. Antifreeze has a deceptive middle stage where the animal appears to improve while the kidneys are failing. Looking fine tonight is not evidence that nothing happened.
Is it worth paying for a poison helpline?
It depends where you are. In the UK, Animal PoisonLine charges £35 in daytime hours and £45 otherwise, and it is a triage service run by the same organisation that advises vets — it can tell you whether you need to go in at all, which is usually cheaper than an out-of-hours consultation. In the US, Pet Poison Helpline is $89 per incident including follow-up calls with your vet. In France, the centre at Nantes is free. Your own vet is always a valid first call, and if your pet is already unwell, skip the helpline and go.
What is the single most time-critical thing on this page?
Lilies and cats. The FDA states that if treatment is delayed 18 hours or more after a cat ingests a true lily or daylily, the cat will generally have irreversible kidney failure — and the exposure can be as small as licking pollen off its fur or drinking vase water. Antifreeze is second: the antidote window for a dog is 8-12 hours.
Why does this tool refuse to calculate some things?
Because no usable threshold has been published for them, and inventing one would be worse than useless in an emergency. Nicotine, lilies, permethrin on cats, anticoagulant rat bait, sago palm and raw bread dough all fall into this category. For grapes the literature gives a risk trigger rather than a dose curve. Saying so is more useful than a fake number that reads as reassurance.
Does this replace a vet?
No, and it is not designed to. It does one narrow job — turning what your pet ate and what it weighs into a dose you can compare against published veterinary thresholds, so that you can have a more useful conversation faster. The AVMA’s framing is the right one: first aid care is not a substitute for veterinary care, but it may save your pet’s life until it receives veterinary treatment.
My dog ate chocolate — how long before symptoms?
Merck states that clinical signs of chocolate toxicosis usually occur within 6-12 hours after ingestion, and that in severe cases they may persist for up to 72 hours. The figure that surprises people is the half-life: theobromine’s half-life in dogs is 17.5 hours, so this is a day-long problem rather than an evening one. An empty first six hours is expected, not reassuring. The timeline on this page shows you where in that window you currently are.
How long do I need to watch my pet after they ate something toxic?
It depends entirely on the substance, and the range is far wider than most people expect. Macadamia signs appear within 12 hours. Chocolate runs 6-12 hours for onset. Xylitol needs liver enzymes checked for at least 72 hours. Onion and garlic damage peaks at 72 hours with anaemia typically appearing 3-5 days later. Anticoagulant rat bait shows nothing at all for the first two to five days and bleeding at 3-7 days. Cholecalciferol needs blood calcium and phosphorus checked at 72-96 hours. Our timeline gives the published window for each one.
When is my pet actually in the clear?
Honestly: for most substances, no published veterinary reference says. Of the eighteen substances on this page, exactly one — cholecalciferol — carries a sentence amounting to an all-clear, and even that one turns on a blood test rather than on how the animal looks: Merck says patients that remain clinically normal and maintain stable, normal calcium and phosphorus values 72-96 hours after ingestion would not be expected to develop signs. Macadamia and THC have published recovery times. For the other fifteen the reference stops before the question does, and we say so rather than inventing a number.
How this page was built
Every threshold comes from the Merck Veterinary Manual, the FDA, VCA Animal Hospitals, Cornell University College of Veterinary Medicine, the AVMA or Pet Poison Helpline, read directly on 27 July 2026 and linked on each row. We publish the arithmetic so you can check it. Where a figure is derived rather than quoted — the feline ibuprofen numbers, which Merck describes only as roughly half the canine dose — we label it as derived.
Some things we deliberately do not do. We do not estimate xylitol content per stick of gum, nicotine per cigarette, or caffeine per cup, because no authoritative source publishes those figures and a made-up number in an emergency is dangerous. We do not apply canine chocolate bands to cats, because feline bands do not exist. And we do not tell you to induce vomiting.
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